1.研究方向: (1)中药药效物质基础及作用机制研究; (2)药用植物资源保护与利用。 2.承担项目: 主持国家自然科学基金1项,省部级项目多项。在Brain Research Bulletin、Frontiers in Aging Neuroscience、Natural Product Research、Medicinal Chemistry Research、中草药、中国中药杂志等刊物发表论文40多篇,获授权专利4件。 [1] 2020年国家自然科学基金青年项目:31900297,主持 [2] 2019年广东省自然科学基金:2018A030307037,主持 [3] 2025年广东省自然科学基金:2025A1515012239,主持 [4] 2021年广东省教育厅创新团队项目:2021KCXTD054,主持 [5] 2023年广东省普通高校特色创新类项目:2023KTSCX069,主持 [6] 2024年广东瑞洋制药有限公司(校企合作项目):广东神曲的药效药理研究及其复方口服液开发项目,主持 [7] 2022年广东丰硒良姜有限公司(校企合作项目):广东徐闻高良姜功能食品开发项目,主持 3.代表论文: [1]Deng MZ,Huang LP*, Zhong XQ. β-asarone modulates Beclin-1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APP/PS1 transgenic mice with Alzheimer's disease. Mol Med Rep. 2020; 21(5): 2095-2102.(SCI,通讯作者) [2]Huang LP, Zhong XQ, Qin SC, Deng MZ*. Protocatechuic acid attenuates β-secretase activity and okadaic acid-induced autophagy via the Akt/GSK3β/MEF2D pathway in PC12 cells. Mol Med Rep. 2020;21(3): 1328-1335.(SCI) [3]Huang LP, Lin MZ, Zhong XQ, Deng MZ*. Galangin decreases p-tau, Aβ42and β-secretase levels, and suppresses autophagy in okadaic acid-induced PC12 cells via an Akt/GSK3β/mTOR signaling-dependent mechanism. Mol Med Rep. 2019;19(3):1767-1774.(SCI) [4]Huang LP,Deng MZ, Zhang S, Lu SY, Gui XH, Fang YQ*. β-asarone and levodopa coadministration increases striatal levels of dopamine and levodopa and improves behavioral competence in Parkinson's rat by enhancing dopa decarboxylase activity. Biomedicine & Pharmacotherapy. 2017; 94: 666-678.(SCI) [5]Huang LP, Deng MZ, He YP, Shiyao Lu, Shu Liu, Fang YQ*. β-asarone increases MEF2D and TH levels and reduces α-synuclein level in 6-OHDA-induced rats via regulating the HSP70/MAPK/MEF2D/Beclin-1 pathway: Chaperone-mediated autophagy activation, macroautophagy inhibition and HSP70 up-expression. Behavioural Brain Research. 2016; 313: 370-379.(SCI) |