科学研究 情况简介 | 1. 主要研究方向：有机功能分子设计合成及应用 2. 承担项目： A. 广东省自科学基金-面上项目（2022A1515011311）：基于醌氧化还原酶响应的纳米药物递送体系的构建及用于耐药性非小细胞肺癌的协同治疗研究； B. 广东省自科学基金-面上项目（2021A1515010203）：基于近红外模式的化学发光诊断治疗型抗癌药物输送体系； C. 广东省自然科学基金-粤东西北创新人才联合培养项目（2018A030307035）：基于硝基还原酶响应的诊断治疗型抗癌前药的设计、合成及应用研究； D. 广东省自科学基金-博士启动基金项目（2017A030310604）：基于醌氧化还原酶响应的诊断治疗型抗癌前药的设计、合成及应用。 3. 代表论文： A. Peilian Liu, Bowen Li(*), Jian Zheng, Qiqi Liang, Cailing Wu, Liping Huang, Peisheng Zhang(*), Yongmei Jia, Wang Sheng(*), A novel N-nitrosation-based ratiometric uorescent probe for highly selective imaging endogenous nitricoxide in living cells and zebrafsh, Sensors & Actuators: B. Chemical, 2021, 329, 129147. B. Yuan Chen, Zhuo Yao, Peilian Liu(*), Qida Hu, Yong Huang, Li Ping, Fu Zhang, Honglin Tang, Tao Wan, Yuan Ping(*), Bowen Li(*), A self-assembly nano-prodrug for triple-negative breast cancer combined treatment by ferroptosis therapy and chemotherapy, Acta Biomaterialia, 2023, 159, 275-288. C. Xueming Xu, Yuan Chen, Jinyong Gui, Peilian Liu(*), Yong Huang, Baihao Shao, Yuan Ping(*), Bowen Li(*), A biomimetic nanodrug self-assembled from small molecules for enhanced ferroptosis therapy, Biomaterials Science, 2022, 10, 770-780. D. Aiqing Feng, Peilian Liu(*), Qiqi Liang, Xinyi Zhang, Liping Huang, Yongmei Jia, Mubiao Xie, Qing Yan, Chengpeng Li, Sheng Wang(*), A new carbazole-based colormetric and ratiometric fluorescent probe for hypochlorite sensing in living cells and zebrafishes, Dyes and Pigments, 2020, 180, 108492. E. Peilian Liu(*), Na Liu, Cuiling Liu, Yongmei Jia, Liping Huang, Guohua Zhou, Chengpeng Li, Sheng Wang (*), A colorimetric and ratiometric fluorescent probe with ultralow detection limit and high selectivity for phosgene sensing, Dyes and Pigments, 2019, 169, 489-495. F. Aiqing Feng, Yongmei Jia, Liping Huang, Lin Wang, Guohua Zhou, Sheng Wang, Peilian Liu(*) , 1,6-Elimination reaction induced detection of fluoride ions in vitro and in vivo based on a NIR fluorescent probe. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 220, 117108. G. Peilian Liu, Bowen Li, Chenyue Zhan, Fang Zeng, Shuizhu Wu, A two-photon-activated prodrug for therapy and drug release monitoring. Journal of Materials Chemistry B, 2017, 5, 7538-7546. H. Bowen Li, Peilian Liu(共同第一作者), Hao Wu, Xin Xie, Zelin Chen, Fang Zeng, Shuizhu Wu, A bioorthogonal nanosystem for imaging and in vivo tumor inhibition. Biomaterials, 2017, 138, 57-68. I. Bowen Li, Peilian Liu(共同第一作者), Donghang Yan, Fang Zeng, Shuizhu Wu, A self-immolative and DT-diaphorase-activatable prodrug for drug-release tracking and therapy. Journal of Materials Chemistry B, 2017, 5, 2635-2643. J. Peilian Liu, Jiangsheng Xu, Donghang Yan, Peisheng Zhang, Fang Zeng, Bowen Li, Shuizhu Wu, A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy. Chemical Communications, 2015, 51, 9567-9570. K. Peilian Liu, Hongren Chen, Stelck Daniel, Deyu Hang, Lei Zhao, Hui Wang, Zhuo Zeng. 3,4-Difluoropyrrole-, 3,3,4,4-tetrafluoropyrrolidine- and pyrrolidine-based liquid crystals. Journal of Fluorine Chemistry, 2013, 156, 327-332. 4. 授权专利 一种化学空间位阻小的可断裂链及其制备方法和应用, 专利号：ZL201811143143.2。 |
